Proton Magnetic Resonance Spectroscopy in Social Anxiety Disorder

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Atıf İçin Kopyala

Tukel R., Aydin K., Yuksel C., Ertekin E., KOYUNCU A.

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, cilt.28, sa.2, ss.138-142, 2016 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 28 Sayı: 2
• Basım Tarihi: 2016
• Doi Numarası: 10.1176/appi.neuropsych.15050115
• Dergi Adı: JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.138-142
• İstanbul Üniversitesi Adresli: Evet

Özet

In the present study, 24 nonmedicated patients with social anxiety disorder (SAD) were compared with 24 healthy control subjects to assess metabolite levels in the anterior cingulate, insula, caudate, and putamen using proton magnetic resonance spectroscopy. The ratio of N-acetylaspartate (NAA)/creatine (Cr) was significantly higher in patients with SAD than in healthy control subjects in the anterior cingulate and insula. NAA/Cr ratios in the insula correlated positively with the Liebowitz Social Anxiety Scale total scores in patients with SAD. Our results support the significance and biochemical involvement of the anterior cingulate and insula in the pathophysiology of SAD.