Analyzing of Alzheimer's Disease Based on Biomedical and Socio-Economic Approach Using Molecular Communication, Artificial Neural Network, and Random Forest Models

BAYRAKTAR Y., Isik E., IŞIK İ., ÖZYILMAZ A., Toprak M., Kahraman Guloglu F., ...More

SUSTAINABILITY, vol.14, no.13, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 13
  • Publication Date: 2022
  • Doi Number: 10.3390/su14137901
  • Journal Name: SUSTAINABILITY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Aerospace Database, CAB Abstracts, Communication Abstracts, Food Science & Technology Abstracts, Geobase, INSPEC, Metadex, Veterinary Science Database, Directory of Open Access Journals, Civil Engineering Abstracts
  • Keywords: Alzheimer's disease, molecular communication, amyloid beta, socioeconomic, random forest, neural network, Turkey, number of received molecules, total population, income inequality, AMYLOID-BETA, EDUCATION, DEMENTIA, DIFFUSION, DETERMINANTS, POPULATION, BIOLOGY, SYSTEMS, RISK
  • Istanbul University Affiliated: Yes


Alzheimer's disease will affect more people with increases in the elderly population, as the elderly population of countries everywhere generally rises significantly. However, other factors such as regional climates, environmental conditions and even eating and drinking habits may trigger Alzheimer's disease or affect the life quality of individuals already suffering from this disease. Today, the subject of biomedical engineering is being studied intensively by many researchers considering that it has the potential to produce solutions to various diseases such as Alzheimer's caused by problems in molecule or cell communication. In this study, firstly, a molecular communication model with the potential to be used in the treatment and/or diagnosis of Alzheimer's disease was proposed, and its results were analyzed with an artificial neural network model. Secondly, the ratio of people suffering from Alzheimer's disease to the total population, along with data of educational status, income inequality, poverty threshold, and the number of the poor in Turkey were subjected to detailed distribution analysis by using the random forest model statistically. As a result of the study, it was determined that a higher income level was causally associated with a lower risk of Alzheimer's disease.