Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?

Cobanoglu H. B., Vuralkan E., Arslan A., Mirasoglu B., Toklu A. S.

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY, cilt.12, sa.1, ss.66-71, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.21053/ceo.2017.01704
  • Dergi Adı: CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.66-71
  • Anahtar Kelimeler: Hyperbaric Oxygen, Cisplatin, Ototoxicity, Rats
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives. Cisplatin is an antineoplastic agent, used in the treatment of different types of malignant neoplasms. Side effects such as ototoxicity, nephrotoxicity, and bone marrow toxicity are the main limitations of its clinical use. The aim of the present study was to evaluate the possible effects of hyperbaric oxygen (HBO) therapy as a protective agent in cisplatin-induced ototoxicity in rats.