Autonomic dysfunction in vitamin B12 deficiency: A heart rate variability study


Sozen A., Demirel S., Akkaya V., Kudat H. , Tukek T. , Yeneral M. N. , ...More

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, vol.71, no.1, pp.25-27, 1998 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 71 Issue: 1
  • Publication Date: 1998
  • Doi Number: 10.1016/s0165-1838(98)00058-7
  • Title of Journal : JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM
  • Page Numbers: pp.25-27
  • Keywords: B12 deficiency, pernicious anemia, megaloblastic anemia, autonomic dysfunction, heart rate variability, spectral analysis, ORTHOSTATIC HYPOTENSION, COBALAMIN DEFICIENCY, ANEMIA

Abstract

This study was arranged to examine whether vitamin B12 deficiency may cause autonomic dysfunction. Time-domain and long-term frequency-domain heart rate variability parameters from 12 patients with pernicious anemia were compared to 12 age and sex matched controls. In B12 deficient patient group time-domain parameters; SDNN (100.4 +/- 37.86 vs. 131.91 +/- 26.94, P = 0.05), SDANN (87.00 +/- 37.77 vs. 118.83 +/- 26.22, P = 0.05) SD (39.41 +/- 13.32 vs. 53.41 +/- 15.39, P = 0.0221), rMSSD (21.41 +/- 10.00 vs. 28.5 +/- 8.42, P = 0.046) were significantly lower when compared to controls. Difference in pNN50 between groups were not statistically significant. In B12 deficient patients frequency-domain parameters; total power (23.08 +/- 9.89 vs. 34.75 +/- 9.56, P = 0.0078), low frequency power (13.5 +/- 6.57 vs. 22.75 +/- 7.25, P = 0.0069) and high frequency power (7.58 +/- 4.25 vs. 11.58 +/- 3.80, P = 0.0175) were significantly lower when compared to controls. It was concluded that B12 deficiency may cause autonomic dysfunction. (C) 1998 Elsevier Science B.V. All rights reserved.