Combined and individual use of pancaspase inhibitor Q-VD-OPh and NMDA receptor antagonist riluzole in experimental spinal cord injury


Can H. , Aydoseli A. , Gomleksiz C., Goker B. , Altunrende M. E. , Dolgun M., ...More

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, vol.23, no.6, pp.452-458, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.5505/tjtes.2017.09694
  • Title of Journal : ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
  • Page Numbers: pp.452-458
  • Keywords: Apoptosis, caspases, necrosis, neuroprotection, NMDA receptor antagonist, pancaspase inhibitor, Q-VD-OPh, riluzole, spinal cord injury, FOCAL CEREBRAL-ISCHEMIA, STRIATONIGRAL DEGENERATION, CASPASE-3 INHIBITOR, APOPTOSIS, RAT, IMPROVES, PHARMACOTHERAPY, MECHANISMS, MEMANTINE, RECOVERY

Abstract

BACKGROUND: We investigated the effects of an N-methyl-D-aspartate receptor antagonist, riluzole, and a pancaspase inhibitor and basic apoptosis mediator, Q-VD-OPh, in combination or alone in posttraumatic spinal cord injury.