As the demand for esthetic treatments is increasing, more people are seeking alternatives to fixed orthodontic appliances. Clear aligners are an esthetic and comfortable option for orthodontic treatment and have gained immense popularity over the last decade. This review will highlight the increasing popularity of clear aligners by describing some aligner systems frequently used today. The scope, limitations, effectiveness, efficacy, and stability of treatment results achieved with this method will be discussed. Further, this paper will assess the possible side effects caused by clear aligner treatment.