Co-expression of plasmid-mediated quinolone resistance-qnrA1 and bla(VEB-1) gene in a Providencia stuartii strain


Nazik H., BEKTORE B., Ongen B., OZYURT M., BAYLAN O., HAZNEDAROGLU T.

NEW MICROBIOLOGICA, vol.34, no.2, pp.225-228, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 2
  • Publication Date: 2011
  • Journal Name: NEW MICROBIOLOGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.225-228
  • Istanbul University Affiliated: Yes

Abstract

Co-expression of plasmid-mediated quinolone resistance-qnrA1 and bla(VEB-1) gene in a Providencia stuartii strain

By:Nazik, H (Nazik, Hasan)2 ] Bektore, B (Bektore, Bayhan)1 ] Ongen, B (Ongen, Betigul)2 ] Ozyurt, M (Ozyurt, Mustafa)1 ] Baylan, O (Baylan, Orhan)1 ] Haznedaroglu, T (Haznedaroglu, Tuncer)1 ]

 

NEW MICROBIOLOGICA

 

Volume: 34

 

Issue: 2

 

Pages: 225-228

Published: APR 2011

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Abstract

An extended-spectrum beta-lactamase (ESBL)-producing Providencia stuartii isolate was studied. A qnrA1 gene co-expressing bla(VEB-1) gene was detected. Both genes were transferred to the recipient strain. The ciprofloxacin MIC of recipient strain increased tenfold. The bla(VEB-1) gene persisted in microorganisms in Turkey but it also spread with PMQR genes to other species. The combination of PMQR with multidrug resistant isolates producing ESBLs may compromise the use of valuable antibiotics. Serious efforts are necessary to detect PMQR determinants not only with common beta-lactamases in widespread pathogens but also with uncommon forms that are encountered infrequently.

An extended-spectrum beta-lactamase (ESBL)-producing Providencia stuartii isolate was studied. A qnrA1 gene co-expressing bla(VEB-1) gene was detected. Both genes were transferred to the recipient strain. The ciprofloxacin MIC of recipient strain increased tenfold. The bla(VEB-1) gene persisted in microorganisms in Turkey but it also spread with PMQR genes to other species. The combination of PMQR with multidrug resistant isolates producing ESBLs may compromise the use of valuable antibiotics. Serious efforts are necessary to detect PMQR determinants not only with common beta-lactamases in widespread pathogens but also with uncommon forms that are encountered infrequently.