Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma

Erdem M., Erdem S., Sanli O., Sak H., Kilicaslan I., Sahin F., ...Daha Fazla

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, cilt.32, sa.1, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.urolonc.2012.08.022
  • Dergi Adı: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Tissue transglutaminase, Renal cell carcinoma, Integrin beta 1, Syndecan-4, Metastasis, TISSUE TRANSGLUTAMINASE EXPRESSION, FIBRONECTIN, ADHESION, SYNDECAN-4, ATTACHMENT, SURVIVAL, PROMOTES, TG2
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Tissue transglutaminase (TGM2) up-regulation is involved in the progression and dissemination of carcinomas through 131 integrin (ITGB1) association. Given that TGM2 interaction with syndecan-4 (SDC4) on the cell surface is important in the activation of ITGB1 and integrin-mediated survival signaling, we investigated the roles of TG.M2. ITGB1, and SDC4 in the development and metastasis of renal cell carcinoma (RUC).