Urine Levels of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Children with Type 1 Diabetes Mellitus

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Yildirim Z. N., Yilmaz A., Pehlivanoglu C., Gedikbasi A., Yuldiz M., Dirican A., ...More

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, vol.11, no.2, pp.157-163, 2019 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 11 Issue: 2
• Publication Date: 2019
• Doi Number: 10.4274/jcrpe.galenos.2018.2018.0221
• Journal Name: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Page Numbers: pp.157-163
• Keywords: Type 1 diabetes mellitus, diabetic nephropathy, children, biomarker, MMP, TIMP, NEPHROPATHY, MATRIX-METALLOPROTEINASE-9, EXPRESSION, DYSREGULATION, PATHOGENESIS, DISEASE, MMP-9
• Istanbul University Affiliated: Yes

Abstract

Objective: Histopathological changes in the kidney in type I diabetes mellitus (T1DM) begin before detection of microalbuminuria. Therefore, there is interest in finding a better biomarker for the early detection of diabetic kidney injury. The aim of this present study was to determine whether urinary indicators of fibrosis are detectable early in the development of T1DM in children and if they may predict progressive renal injury.