Severe vitamin D deficiency is associated with endothelial inflammation in healthy individuals even in the absence of subclinical atherosclerosis
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.26, sa.19, ss.7046-7052, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 19
- Basım Tarihi: 2022
- Doi Numarası: 10.26355/eurrev_202210_29888
- Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
- Sayfa Sayıları: ss.7046-7052
- Anahtar Kelimeler: Key Endocan, Vitamin D deficiency, Atherosclerosis, Endothelial inflammation, ENDOCAN LEVELS, 25-HYDROXYVITAMIN-D, DISEASE, RISK, EXPRESSION, PREVENTION, CANCER, GENE
- İstanbul Üniversitesi Adresli: Evet
Özet
- OBJECTIVE: Vitamin D has bene-ficial effects, some of which involve the cardio-vascular system. No study to date has investigat-ed the association between serum endocan levels, as a biomarker of endothelial inflammation, and vitamin D levels in the absence of subclinical atherosclerosis detected by carotid intima-media thickness (CIMT) in healthy individuals. PATIENTS AND METHODS: Subjects were categorized into three groups based on vitamin D levels according to Endocrine Society guide-lines. Mean CIMT was calculated from six mea-surements on two scans. Statistical significance was set at p < 0.05, and all testing was two-sided. RESULTS: The concentration of serum endocan was 802.8 +/- 411.4 ng/L in the group with the lowest serum vitamin D level, 454.8 +/- 334.3 ng/L in the mild/ moderately low serum vitamin D level group, and 269.4 +/- 180.2 ng/L in the group with normal serum vitamin D levels (p < 0.01). Receiver operating char-acteristics curve analysis revealed that a serum vita-min D concentration of 7.5 ng/mL had a 97% sensi-tivity and 81% specificity for the prediction of serum endocan level greater than 270 ng/L, which could be an indicator for endothelial inflammation. CONCLUSIONS: Demonstrating that vitamin D deficiency can cause endothelial damage in the early period of atherosclerosis without the development of clinical cardiovascular disease will have a pivotal role in the prevention of car-diovascular mortality and morbidity.