Frequency of CCR5-Delta 32, CCR2-64I and SDF1-3 ' A alleles in HIV-infected and uninfected patients in Istanbul, Turkey

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Köksal M. O., Akgül B., Beka H., Çiftçi S., Keskin F., Eraksoy H., ...More

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, vol.15, no.8, pp.1183-1189, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 8
  • Publication Date: 2021
  • Doi Number: 10.3855/jidc.12861
  • Journal Name: JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.1183-1189
  • Keywords: AIDS, HIV-1, CCR5-Delta 32, SDF1-3 ' A, genetics, epidemiology, CHEMOKINE RECEPTOR GENE, POLYMORPHISMS, CCR5, RESISTANCE, VARIANTS, SUSCEPTIBILITY, PROTECTION, SDF-1
  • Istanbul University Affiliated: Yes

Abstract

Introduction: Co-receptors involved in cell entry of the human immunodeficiency virus (HIV) and mutations in genes encoding their ligands may play a role in the susceptibility to infection and resistance to the progression of the infection. The best studied mutations that can exist in these genes are the CCR5-Delta 32, CCR2-64I and SDF1-3'A mutations. The frequency of these mutations vary from continent to continent and even from region to region. However, there is limited information on their distribution throughout the Turkish population. Istanbul is the city with the highest number of documented HIV-infected patients in Turkey, which can be attributed to the population size. The aim of this study was to determine the distribution of three AIDS-related gene variants among HIV-infected and uninfected population in Istanbul, Turkey and to estimate the contribution of these variants to susceptibility or resistance to HIV.