Miliaria rubra and thrombocytosis in pseudohypoaldosteronism: Case report
PLATELETS, vol.23, no.8, pp.645-647, 2012 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 23 Issue: 8
- Publication Date: 2012
- Doi Number: 10.3109/09537104.2011.641624
- Journal Name: PLATELETS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.645-647
- Keywords: Pseudohypoaldosteronism, thrombocytosis, miliaria rubra, I PSEUDOHYPOALDOSTERONISM
- Istanbul University Affiliated: Yes
Abstract
Pseudohypoaldosteronism type 1 (PHA1) is a disease involving a state of renal tubular unresponsiveness to the action of aldosterone and characterized by excessive salt loss in the urine, hyperkalemia, and metabolic acidosis. In kidney, PHA1 may occur primarily by mutations in the subunits of the sodium channel or in the mineralocorticoid receptors, and secondarily by several renal disorders. Miliaria rubra and thrombocytosis are reported in a 6-month-old girl with PHA1. In patients with PHA1, miliaria rubra-like cutaneous eruptions are suggested to occur due to obstruction of eccrine sweat glands through inflammation caused by excessive sodium excretion in sweat during hyponatremic crises. The presence of thrombocytosis in patients with PHA1 has not been previously reported. A hypothesis is proposed suggesting that sympathetic activation which provides vascular tonus during sodium excretion in sweat and salt-depletion crisis may play a role in the development of eruptions and thrombocytosis in patients with PHA1.