Oxytocin as a protective agent in cisplatin-induced ototoxicity

Bılmez, Zekiye; Aydin, Sedat; Sanlı, Arif; Altıntoprak, Niyazi; Demir, Mehmet; Erdogan, Banu; Kosemihal, Ebru

doi:10.1007/s00280-016-2978-x

Oxytocin as a protective agent in cisplatin-induced ototoxicity

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Bılmez Z. E. B., Aydin S., Sanlı A., Altıntoprak N., Demir M. G., Erdogan B. A., ...More

CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol.77, no.4, pp.875-879, 2016 (SCI-Expanded)

Publication Type: Article / Article
Volume: 77 Issue: 4
Publication Date: 2016
Doi Number: 10.1007/s00280-016-2978-x
Journal Name: CANCER CHEMOTHERAPY AND PHARMACOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.875-879
Istanbul University Affiliated: No

Abstract

Cisplatin is a potent chemotherapeutic drug with serious side effects such as ototoxicity which is characterized by irreversible, bilateral, progressive sensorineural hearing loss. Oxytocin, which is a well-known hormone secreting during pregnancy, has antioxidant and antiinflammatory effect. Our study aims to test and compare the effect of intratympanic (IT) and intraperitoneal (IP) oxytocin on cisplatin ototoxicity with DPOAE.