Angiotensin-converting enzyme I/D gene polymorphisms and effects of left ventricular hypertrophy in Turkish myocardial infarction patients

KARAALI Z., Agachan B., YILMAZ H., ISBIR T.

ACTA CARDIOLOGICA, cilt.59, sa.5, ss.493-497, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 5
  • Basım Tarihi: 2004
  • Doi Numarası: 10.2143/ac.59.5.2005221
  • Dergi Adı: ACTA CARDIOLOGICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.493-497
  • Anahtar Kelimeler: angiotensin-converting enzyme polymorphism, left ventricular hypertrophy, myocardial infarction, CORONARY-ARTERY-DISEASE, IDIOPATHIC DILATED CARDIOMYOPATHY, INSERTION DELETION POLYMORPHISM, DEPENDENT DIABETES-MELLITUS, ISCHEMIC-HEART-DISEASE, INCREASED RISK, ASSOCIATION, LOCUS, HYPERTENSION, POPULATIONS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective - Since the initial report of the association of the deletion/insertion (D/I) polymorphism in the gene for angiotensin-converting enzyme (ACE) with myocardial infarction (MI), there has been considerable controversy. Some have found the D allele to be associated with MI, coronary heart disease (CHD) or other cardiac pathologies, while others have not. In view of the clinical importance of the ACE as a major marker of cardiovascular diseases, we investigated the I/D polymorphism of the ACE gene in Turkish patients with acute myocardial infarction in comparison with control subjects.