THE EFFECT OF TOXIC DOSES OF CHOLECALCIFEROL (VITAMIN-D3) ON THE SERUM ZINC LEVELS IN RATS

GUVEN Y., YILDIRIM S., KASAPOGLU C.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.37, sa.1, ss.85-89, 1993 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 1
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1007/bf02789403
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.85-89
  • İstanbul Üniversitesi Adresli: Evet

Özet

Zinc is a trace element important to bone mineralization as well as, in general, nutrition. It is known that cholecalciferol (vitamin D3) affects bone metabolism. In this study, toxic doses of vitamin D3 were injected subcutaneously (25 mug/d) to rats for 5 wk. It caused a significant increase in serum zinc levels (p < 0.02). On the other hand, no significant increase was detected in the other groups. Excessive amounts of vitamin D3 caused bone breakdown and increased the levels of zinc in blood.