Free DNA in Circulation and its Importance

PEHLİVAN S., Avci S., Sever T., Bayram A., OĞUZKAN BALCI S.

EUROPEAN JOURNAL OF THERAPEUTICS, cilt.16, sa.2, ss.75-80, 2010 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 2
  • Basım Tarihi: 2010
  • Dergi Adı: EUROPEAN JOURNAL OF THERAPEUTICS
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.75-80
  • Anahtar Kelimeler: Cell free DNA, Apoptosis, Necrosis, Genetic diagnosis
  • İstanbul Üniversitesi Adresli: Evet

Özet

The cell-free, nude and double helix structured DNA, which joins circulation for reasons such as cell necrosis and programmed cell death (apoptosis) and is obtained try the purification of plazma or serum samples in the circulatory system, is called Free DNA (fDNA). Although it is advocated to have existed approximately 130 years ago, its importance has been understood better for the last 20 years, and it preserves its place among the cases in which intensive studies are made in many fields of medicine such as Hematology, Gynecology and Obstetrics, Urology, Oncology, Surgery and Neurology. In this collection, it will be intended to summarize literature information wherein it is intended to answer questions such as what Free DNA is, in which fields it is studied more intensively and whether it yields promising results in diagnosis and treatment for the future,