The effects of prochloraz on the levels of nuclear receptor genes expressions and global DNA methylation in human prostate carcinoma cells

Karaman E. F., Dogan E., Alga D., Ozden S.

ISTANBUL JOURNAL OF PHARMACY, cilt.51, sa.2, ss.191-197, 2021 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.26650/istanbuljpharm.2021.850791
  • Dergi Adı: ISTANBUL JOURNAL OF PHARMACY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.191-197
  • Anahtar Kelimeler: Cytotoxicity, DNA methylation, nuclear receptor genes, PC-3 cells, prochloraz, ARYL-HYDROCARBON RECEPTOR, CURRENTLY USED PESTICIDES, FUNGICIDE PROCHLORAZ, PPAR-GAMMA, BIOTRANSFORMATION ENZYMES, (TRI)AZOLE FUNGICIDES, IMIDAZOLE FUNGICIDE, OXIDATIVE STRESS, CYTO-TOXICITY, IN-VITRO
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background and Aims: Prochloraz (PCZ) is an imidazole fungicide which is used in agriculture and gardening. PCZ, with endocrine disrupting effect, disrupts reproductive and developmental functions. Previously, the effects of PCZ on the estrogen and androgen receptors have been shown in vitro and in vivo. Because of endocrine disrupting effects, PCZ could influence nuclear receptors which acted as ER and AR antagonists. Besides, PCZ has been thought to have no genotoxic effects. Therefore, we aimed to investigate possible effects of PCZ on nuclear receptor genes and epigenetic mechanisms in human prostate carcinoma (PC-3) cells.