The effects of prochloraz on the levels of nuclear receptor genes expressions and global DNA methylation in human prostate carcinoma cells


Karaman E. F., Dogan E., Alga D., Ozden S.

ISTANBUL JOURNAL OF PHARMACY, vol.51, no.2, pp.191-197, 2021 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.26650/istanbuljpharm.2021.850791
  • Journal Name: ISTANBUL JOURNAL OF PHARMACY
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.191-197
  • Keywords: Cytotoxicity, DNA methylation, nuclear receptor genes, PC-3 cells, prochloraz, ARYL-HYDROCARBON RECEPTOR, CURRENTLY USED PESTICIDES, FUNGICIDE PROCHLORAZ, PPAR-GAMMA, BIOTRANSFORMATION ENZYMES, (TRI)AZOLE FUNGICIDES, IMIDAZOLE FUNGICIDE, OXIDATIVE STRESS, CYTO-TOXICITY, IN-VITRO
  • Istanbul University Affiliated: Yes

Abstract

Background and Aims: Prochloraz (PCZ) is an imidazole fungicide which is used in agriculture and gardening. PCZ, with endocrine disrupting effect, disrupts reproductive and developmental functions. Previously, the effects of PCZ on the estrogen and androgen receptors have been shown in vitro and in vivo. Because of endocrine disrupting effects, PCZ could influence nuclear receptors which acted as ER and AR antagonists. Besides, PCZ has been thought to have no genotoxic effects. Therefore, we aimed to investigate possible effects of PCZ on nuclear receptor genes and epigenetic mechanisms in human prostate carcinoma (PC-3) cells.