Effect of magnesium sulfate administration on blood-brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study

Esen F. , Erdem T. L. , Aktan D. , Orhan M. , Kaya M. , Eraksoy H., ...More

CRITICAL CARE, vol.9, no.1, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1186/cc3004
  • Title of Journal : CRITICAL CARE
  • Keywords: blood-brain barrier, brain edema, magnesium, sepsis, septic encephalopathy, CLOSED-HEAD INJURY, SEPTIC ENCEPHALOPATHY, CEREBRAL EDEMA, PERMEABILITY, THERAPY


Introduction Permeability changes in the blood - brain barrier (BBB) and their possible contribution to brain edema formation have a crucial role in the pathophysiology of septic encephalopathy. Magnesium sulfate has been shown to have a protective effect on BBB integrity in multiple experimental models. In this study we determine whether magnesium sulfate administration could have any protective effects on BBB derangement in a rat model of sepsis.