Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats

ARICIOĞLU F., Ozkartal C. S., Bastaskin T., Tuzun E., Kandemir C., ŞİRVANCI S., ...More

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, vol.17, no.2, pp.261-272, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 2
  • Publication Date: 2019
  • Doi Number: 10.9758/cpn.2019.17.2.261
  • Journal Name: CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.261-272
  • Keywords: Depression, Coomassie Brilliant Blue, ATP receptor, Purinergic P2X7 receptors, Animal models, BRILLIANT BLUE G, NLRP3 INFLAMMASOME, P2RX7 GENE, GLN460ARG POLYMORPHISM, MICROGLIAL ACTIVATION, PSYCHOLOGICAL STRESS, ANIMAL-MODELS, GLOBAL BURDEN, MOUSE MODEL, PATHOPHYSIOLOGY
  • Istanbul University Affiliated: Yes

Abstract

Objective: Purinergic 2X7 receptor (P2X7R) activation is known to be involved in pathogenesis of depression. Our aims were to investigate P2X7R-activated inflammasome pathways in parallel with induction of depression and to test the antidepressant-like effects of the selective P2X7R antagonist Brilliant Blue G (BBG) in a rat model of chronic unpredictable mild stress (CUMS).