CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, vol.17, no.2, pp.261-272, 2019 (Journal Indexed in SCI)
Article / Article
Title of Journal :
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
Depression, Coomassie Brilliant Blue, ATP receptor, Purinergic P2X7 receptors, Animal models, BRILLIANT BLUE G, NLRP3 INFLAMMASOME, P2RX7 GENE, GLN460ARG POLYMORPHISM, MICROGLIAL ACTIVATION, PSYCHOLOGICAL STRESS, ANIMAL-MODELS, GLOBAL BURDEN, MOUSE MODEL, PATHOPHYSIOLOGY
Objective: Purinergic 2X7 receptor (P2X7R) activation is known to be involved in pathogenesis of depression. Our aims were to investigate P2X7R-activated inflammasome pathways in parallel with induction of depression and to test the antidepressant-like effects of the selective P2X7R antagonist Brilliant Blue G (BBG) in a rat model of chronic unpredictable mild stress (CUMS).