c-erbB-2 gene amplification in nasopharyngeal carcinoma

Yazici H., ALTUN M., ALATLI C., DOGAN O., DALAY N.

CANCER INVESTIGATION, cilt.18, sa.1, ss.6-10, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2000
  • Doi Numarası: 10.3109/07357900009023056
  • Dergi Adı: CANCER INVESTIGATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6-10
  • İstanbul Üniversitesi Adresli: Evet

Özet

Amplification of the c-erbB-2 gene has been associated with poor prognosis in different types of cancer. However, there are no data an the c-erbB-2 expression levels in nasopharyngeal cancer. In this study, amplification of the gene has been investigated in the tumor tissue of patients with nasopharyngeal cancer by competitive polymerase chain reaction c-ErbB-2 amplification was observed in 43.3% of the patients. The increase in the gene copy number correlated with the T stage. No correlation was found with lymph node involvement, histologic grade, differentiation, presence of metastases, or age and sex. We conclude that c-erbB-2 amplification may contribute to the pathogenesis of nasopharyngeal cancer. Our report is the first study investigating the expression of the c-erbB-2 gene in nasopharyngeal cancer at the DNA level.