Chronic granulomatous disease presenting with invasive aspergillosis and hypogammaglobulinemia

Keles S., Soysal A., ÖZDEMİR C., Eifan A. O., Bahceciler N., Bakir M., ...Daha Fazla

ASTIM ALLERJI IMMUNOLOJI, cilt.7, sa.3, ss.189-193, 2009 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 3
  • Basım Tarihi: 2009
  • Dergi Adı: ASTIM ALLERJI IMMUNOLOJI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.189-193
  • Anahtar Kelimeler: Granulomatous disease, chronic, child, hypogammaglobulinemia, invasive pulmonary aspergillosis, aspergillosis
  • İstanbul Üniversitesi Adresli: Evet

Özet

Chronic granulomatous disease (CGD) is a rare disorder with the unifying characteristics of severe predisposition to bacterial and fungal infections, impaired ability of phagocytic leukocytes to produce microbicidal oxygen metabolites and failure of these cells to kill certain microorganisms. Aspergillus spp. are the most common fungal pathogens in these patients. Cranial aspergillosis is a rare presentation with a high mortality rate. Immunoglobulin levels of CGD patients are usually normal or elevated. We herein describe a five-year-old boy with CGD presenting with disseminated aspergillosis and hypogammaglobulinemia (low IgA and IgG).