Secondary hemophagocytic lymphohistiocytosis induced by malaria infection in a child with Langerhans cell histiocytosis

Sarıbeyoğlu E., Anak S. S., Agaoglu L., Boral O., Unuvar A., Devecioğlu Ö.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.21, sa.3, ss.267-272, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/08880010490277060
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.267-272
  • Anahtar Kelimeler: Langerhans cell histiocytosis, malaria infection, secondary hemophagocytic lymphohistiocytosis, virus-associated hemophagocytic syndrome, MIMICKING MALIGNANT HISTIOCYTOSIS, EPSTEIN-BARR VIRUS, FALCIPARUM-MALARIA
  • İstanbul Üniversitesi Adresli: Evet

Özet

Since the first description of infection-associated hemophagocytosis (IAHS), the list of precipitating infectious agents causing hemophagocytic syndrome has grown. A lymphohistiocytic proliferation with hemophagocytosis may develop as a result of macrophage activation, viral or bacterial infection, parasitic infestations, or malignancy. The authors report on a 3-year-old boy with Langerhans cell histiocytosis (LCH), who developed IAHS during malaria infection. Hemophagocytic syndromes may complicate the course of LCH and cause diagnostic problems. Malaria is one of many infections that can precipitate secondary hemophagocytic lymphohistiocytosis.

Since the first description of infection-associated hemophagocytosis (IAHS), the list of precipitating infectious agents causing hemophagocytic syndrome has grown. A lymphohistiocytic proliferation with hemophagocytosis may develop as a result of macrophage activation, viral or bacterial infection, parasitic infestations, or malignancy. The authors report on a 3-year-old boy with Langerhans cell histiocytosis (LCH), who developed IAHS during malaria infection. Hemophagocytic syndromes may complicate the course of LCH and cause diagnostic problems. Malaria is one of many infections that can precipitate secondary hemophagocytic lymphohistiocytosis.