Effects of Bone Morphogenetic Proteins on Osteoblast Cells: Vascular Endothelial Growth Factor, Calcium, Inorganic Phosphate, and Nitric Oxide Levels

Emes Y., Aybar B., Vural P., Saral N. Y., Atalay B., Kaya A. S., ...Daha Fazla

IMPLANT DENTISTRY, cilt.19, sa.5, ss.419-427, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1097/id.0b013e3181e5d5d4
  • Dergi Adı: IMPLANT DENTISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.419-427
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: Bone morphogenetic proteins (BMPs) play an important role in the initiation of bone formation by affecting cell growth and differentiation in a variety of cell types including osteoblasts. Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and vasculogenesis, and also, VEGF signaling is important for skeletal development. Nitric oxide (NO), calcium (Ca), and inorganic Phosphate (Pi) are important molecules for cell functions. In this study, the effects of BMP on VEGF, Ca, NO, and Pi levels were investigated in an osteoblast cell culture.