Effect of maximum-tolerated doses and low-dose metronomic chemotherapy on serum vascular endothelial growth factor and thrombospondin-1 levels in patients with advanced nonsmall cell lung cancer

Tas F., Duranyildiz D., Soydinc H. O., Cicin I., Selam M., Uygun K., ...Daha Fazla

CANCER CHEMOTHERAPY AND PHARMACOLOGY, cilt.61, sa.5, ss.721-725, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1007/s00280-007-0526-4
  • Dergi Adı: CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.721-725
  • Anahtar Kelimeler: metronomic chemotherapy, MTD chemotherapy, serum, VEGF, TSP1, ANGIOGENESIS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background Angiogenesis is regulated by a balance of both angiogenic inducers and inhibitors. This study was designed to evaluate the effect of both maximum-tolerated doses (MTD) and low-dose metronomic chemotherapy (LDM) on serum vascular endothelial growth factor (VEGF), thrombospondin-1 (TSP1) and VEGFR1 concentrations in patients with advanced nonsmall cell lung cancer.