Brain Infiltration of Immune Cells in CASPR2-Antibody Associated Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Unverengil G., Vanli Yavuz E. N., Tuzun E., Erdag E., Kabadayi S., Bilgic B., ...More

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, vol.53, no.4, pp.344-347, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 53 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.5152/npa.2016.15932
  • Journal Name: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.344-347
  • Keywords: Antibody, CASPR2, hippocampal sclerosis, temporal lobe epilepsy, autoimmunity, ANTI-NMDAR ENCEPHALITIS, LIMBIC ENCEPHALITIS, FOCAL EPILEPSY, ANTIBODIES, AUTOANTIBODIES, COMPLEMENT
  • Istanbul University Affiliated: Yes

Abstract

Introduction: Antibodies directed against neuronal surface antigens have recently been identified in patients with focal temporal lobe epilepsy (TLE) of unknown cause and mesial TLE with hippocampal sclerosis (MTLE-HS), thereby emphasizing the role of autoimmunity in TLE. Antibodies to contactin-associated protein-like 2 (CASPR2) are prevalent in MTLE-HS patients. We aimed to find out whether anti-neuronal autoimmunity might be involved in CASPR2 antibodyrelated MTLE-HS.