Amphiphysin Autoimmunity: Associated Neurological Syndromes and Tumors in The Turkish Population


Tuzun E., Bebek N., Icoz S., Durmus H., Kurtuncu M., Gurses C., ...More

JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH, vol.27, no.2, pp.121-126, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 2
  • Publication Date: 2010
  • Journal Name: JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.121-126
  • Istanbul University Affiliated: Yes

Abstract

Objective: Our aim was to determine the clinical accompaniments of the amphiphysin autoimmunity in the Turkish population. Patients and Methods: Sera of 6 patients with a subacute neurological presentation were selected because of their immunoreactivity pattern suggestive of amphiphysin-antibodies. Amphiphysin-antibody positivity was confirmed by immunoblots containing recombinant amphiphysin protein. Results: Two patients had limbic encephalitis, 1 myelopathy and 3 neuropathy. Breast, lung and endometrium cancers were detected in one patient each. Two patients had metastasis ( of a bladder cancer and an unknown tumor) and no tumors could be found in one patient. Most or all patients exhibited normal imaging and cerebrospinal fluid (CSF) findings and poor response to immunosuppression. None of the patients' sera contained antibodies to other intracellular paraneoplastic antigens. Conclusions: Our cohort differs from the previously reported ones by reduced frequency of abnormal CSF findings, absence of other coexisting paraneoplastic antibodies and presence of tumor types that have not been previously associated with amphiphysin autoimmunity.