Effects of NSAIDs and Hydroxyapatite Coating on Osseointegration: Biomechanical and Histological Study on Rabbits
Tez Türü: Tıpta Uzmanlık
Tezin Yürütüldüğü Kurum: İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Türkiye
Tez Danışmanı: Önder İsmet Kılıçoğlu
Tezin Onay Tarihi: 2010
Tezin Dili: Türkçe
Desteklendiği Program: Diğer
Özet:
Purpose: The aim of our study is to investigate the bone ongrowth of two different alternative surfaces and the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on osseointegration.
Methods: Hips of forty New Zealand white rabbits were operated bilaterally. HA coated titanium rods were implanted into the right femur and grit blasted titanium rods were implanted into the left femur. They were divided into three groups. At the end of 8 weeks both femora of the rabbits were removed, and investigated biomechanically and histologically.
Results: HA coated implants had a significantly better failure load and ‘percentage of bone-implant contact’ than grit blasted implants. There was no significant difference between the medication groups as a result of the biomechanical and histologic investigations.
Conclusions: Our results indicate that, NSAIDs did not have any negative effect on the osseointegration. HA coated implants may provide more tensile strength and greater bone-implant contact rate in comparison with grit blasted implants.