Molecular Mechanisms of Quercitrin-induced Apoptosis in Non-small Cell Lung Cancer

Cincin Z. B., Unlu M., Kiran B., Bireller E. S., Baran Y., Cakmakoglu B.

ARCHIVES OF MEDICAL RESEARCH, vol.45, no.6, pp.445-454, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 6
  • Publication Date: 2014
  • Doi Number: 10.1016/j.arcmed.2014.08.002
  • Journal Name: ARCHIVES OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.445-454
  • Keywords: Non-small cell lung cancer, Quercitrin, Apoptosis, Microarray, QUERCETIN, FLAVONOIDS, INHIBITION, RESISTANCE, INDUCTION, PROTECTS, GROWTH
  • Istanbul University Affiliated: Yes

Abstract

Background and Aims. Quercitrin (QR; quercetin-3-0-rhamnoside) has been used previously as an antibacterial agent and has been shown to inhibit the oxidation of low-density lipoproteins and prevent an allergic reaction. Furthermore, it was demonstrated that quercitrin exerts protective effects against H2O2-induced dysfunction in lung fibroblast cells. However, the mechanisms of quercitrin effects on cancer cell proliferation and apoptosis is not well understood. The aim of this study is to investigate the cytotoxic and apoptotic effects of quercitrin and the molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer (NSCLC) cell lines.