The formation of polycomplexes of poly(methyl vinyl ether-CO-maleic anhydride) and bovine serum albumin in the presence of copper ions


Karahan M., Mustafaeva Z., Ozeroglu C.

POLISH JOURNAL OF CHEMICAL TECHNOLOGY, vol.16, no.3, pp.97-105, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 3
  • Publication Date: 2014
  • Doi Number: 10.2478/pjct-2014-0058
  • Title of Journal : POLISH JOURNAL OF CHEMICAL TECHNOLOGY
  • Page Numbers: pp.97-105

Abstract

The binary and ternary complex formations of poly(methyl vinyl ether-co-maleic anhydride) (PMVEMA) with copper ions and with bovine serum albumin (BSA) in the presence of copper ions in phosphate buffer solution at pH = 7 were examined by the techniques of UV-visible, fl uorescence, dynamic light scattering, atomic force microscopy measurements. In the formation of binary complexes of PMVEMA-Cu(II), the addition of copper ions to the solution of PMVEMA in phosphate buffer solution at pH = 7 forms homogeneous solutions when the molar ratio of Cu(II)/MVEMA is 0.5. Then the formations of ternary complexes of PMVEMA-Cu(II)-BSA were examined. Study analysis revealed that the toxicities of polymer-metal and polymer-metal-protein mixture solutions depend on the nature and ratio of components in mixtures.