Evaluation of selenoproteins and proinflammatory cytokines in L-thyroxine-induced hyperthyroid rats: effects of selenium supplementation

Creative Commons License

YOLDAŞ A., BAHTİYAR N., ÇAKIR AYDEMİR B., Toplan S.

ARCHIVES OF ENDOCRINOLOGY METABOLISM, cilt.69, sa.2, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.20945/2359-4292-2024-0444
  • Dergi Adı: ARCHIVES OF ENDOCRINOLOGY METABOLISM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE, Directory of Open Access Journals
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: This study investigated the effects of selenium, which is known for its antioxidant and immune-supporting properties, on serum levels of thyroid function markers, selenoproteins, and proinflammatory cytokines in a model of hyperthyroidism. Materials and methods: A total of 48 Wistar albino rats were distributed into 6 groups: a control group; a hyperthyroid group (HT group); a group fed 0.5 mg/kg sodium selenite (Se 1 group); a group fed 1 mg/kg sodium selenite (Se 2 group); a hyperthyroid group fed 0.5 mg/kg sodium selenite (HT + Se 1 group); and a hyperthyroid group fed 1 mg/kg sodium selenite (HT + Se 2 group) added to standard fodder. Serum levels of interleukin (IL)-1(3, IL-6, IL-18, tumour necrosis factor alpha (TNF-alpha), selenoprotein P (SelP), and glutathione peroxidase 1 (GPx1) were measured using ELISAs. Results: IL-I(3, IL-6, IL-18, and TNF-alpha levels were increased, but selenium, GPx1, and SelP levels were decreased in the hyperthyroid group compared with those in the control group. Selenium and GPx1 levels were increased, but TNF-alpha levels were decreased in the HT + Se 1 group compared with those in the HT group. Selenium, SelP, and GPx1 levels were increased, but TNF-alpha, IL-6, and IL-18 levels were decreased in the HT + Se 2 group compared with those in the HT group. Conclusion: Our results suggest that appropriate doses of selenium may be effective at preventing inflammation and providing protection against oxidative stress in hyperthyroid rats.