The relationship between common geriatric syndromes and potentially inappropriate medication use among older adults

Creative Commons License

Küçükdağlı P., Bahat G., Bay I., Kılıç C., Oren M. M., Özulu Türkmen B., ...Daha Fazla

AGING CLINICAL AND EXPERIMENTAL RESEARCH, cilt.32, sa.4, ss.681-687, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s40520-019-01239-x
  • Dergi Adı: AGING CLINICAL AND EXPERIMENTAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Abstracts in Social Gerontology, AgeLine, CAB Abstracts, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.681-687
  • Anahtar Kelimeler: Inappropriate medication use, Geriatric syndromes, Beers criteria, ADVERSE DRUG EVENTS, NURSING-HOME, EXPLICIT CRITERIA, SCREENING TOOL, RISK-FACTORS, PERSONS PRESCRIPTIONS, ELDERLY-PATIENTS, BEERS 2012, POLYPHARMACY, PREVALENCE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background/aim: Polypharmacy and inappropriate medication use in older adults is a major public health problem associated with morbidity and mortality. Aging is associated with metabolic changes and decreased drug clearance, increased drug-drug interactions, prescribing cascades, and potentially inappropriate medication (PIM) use. The purpose of this study was to evaluate the association between a common geriatric syndromes and PIM use among older adults.

Methods: Study participants were recruited among patients admitted to Istanbul Medical School Geriatrics outpatient clinic between June 2000 and June 2014 and were evaluated retrospectively by a geriatrician using the patients' records according to Beers 2012 criteria.

Results: Among the 667 enrolled patients, 421 (63.1%) were women and 246 (36.9%) were men. The use of PIM was not associated with age or sex. Polypharmacy (OR 4.86, 95% CI 3.25-7.27, p < 0.001), malnutrition (OR 2.69, 95% CI 1.52-4.76, p = 0.001), depression (OR 2.61, 95% CI 1.7-3.95, p < 0.001), presence of fall in the previous year (OR 2.24, 95% CI 1.51-3.32, p < 0.001), and dementia (OR 1.69, 95% CI 1.08-2.65, p = 0.021) were independently associated with the use of PIM.

Discussion/conclusions: The results of our study suggest that PIM use is independently associated with presence of polypharmacy, malnutrition, depression, falls and dementia in older outpatients. Identifying the association of inappropriate medication use with common geriatric syndromes in older people can help to prevent, delay, and reduce PIM use and related adverse health outcomes.