Cell studies on Electrohydrodynamic (EHD)-3D-bioprinted Bacterial Cellulose\Polycaprolactone scaffolds for tissue engineering

Altun E., EKREN N., Kuruca S. E., GÜNDÜZ O.

MATERIALS LETTERS, vol.234, pp.163-167, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 234
  • Publication Date: 2019
  • Doi Number: 10.1016/j.matlet.2018.09.085
  • Journal Name: MATERIALS LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.163-167
  • Keywords: EHD-3D-bioprinting, Biomaterials, Polymers, Bacterial Cellulose, Polycaprolactone, IN-VITRO, 3D
  • Istanbul University Affiliated: Yes

Abstract

The application of three-dimensional (3D) printed scaffolds for tissue engineering have gained significant attention in recent years. The biological activity of scaffolds used in tissue engineering applications depends on fabricating high-resolution patterns with fiber orientation and scale. In this study, Bacterial Cellulose (BC) and Polycaprolactone (PCL) composite scaffolds with the line spacing of 100 mu m are produced using Electrohydrodynamic (EHD)-3D-bioprinting technique. The composite scaffolds exhibit enhanced biocompatibility with facilitated cell attachment and proliferation in vitro. The results of this work have demonstrated that EHD-3D-bioprinting method shows great potential for the preparation of BC/PCL composite scaffold and patterns for tissue engineering with enhanced bioactivity. (C) 2018 Published by Elsevier B.V.