NK cell subsets and their role in allergy

Deniz G., Akdiş M.

EXPERT OPINION ON BIOLOGICAL THERAPY, vol.11, no.7, pp.833-841, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 11 Issue: 7
  • Publication Date: 2011
  • Doi Number: 10.1517/14712598.2011.572549
  • Journal Name: EXPERT OPINION ON BIOLOGICAL THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.833-841
  • Keywords: allergy, cytokines, cytotoxicity, NK cell subsets, NK cells, NATURAL-KILLER-CELLS, T-CELLS, ATOPIC-DERMATITIS, INHIBITORY RECEPTORS, MUCOSAL IMMUNITY, SURFACE-MOLECULE, DENDRITIC CELLS, INNATE IMMUNITY, TUMOR-CELLS, IN-VIVO
  • Istanbul University Affiliated: Yes

Abstract

Introduction: NK cells represent a distinct lymphocyte population with extensive cytolytic activity and a variety of other functions, including regulation of hemopoiesis, suppressor functions and immunoglobulin production. Recently, reports suggest that NK cells also display potent regulatory functions via secretion of cytokines or cell-contact-dependent mechanisms. Thus NK cells may regulate innate and adaptive immune responses and play a role in immune homeostasis.