Introduction: The amplitudes of F-waves and motor-evoked potentials (MEPs) increase during imagination or active motor performance. The aim of this study was to investigate F-wave and MEP facilitation during assessment of apraxia. Methods: Eight Parkinson disease (PD) patients with apraxia, 11 patients without apraxia, and 8 healthy volunteers were enrolled. F-waves and MEPs were recorded during 4 states (resting, imagination, observation, and active movement). Results: The mean amplitude of the F-waves increased significantly during imagination and active movement as compared with at rest in healthy individuals (P = 0.028) and in the nonapraxia group (P = 0.005). PD patients with apraxia did not have similar facilitation. The mean amplitude of the MEPs also showed a similar loss of facilitation in PD with apraxia. Conclusions: Loss of facilitation during the preparation for movement is closely related to the "gold standard" clinical praxis battery. This study provides additional support and a potential electrophysiological assessment method for apraxia in PD.