Effect of antiepileptic drugs on erythrocyte osmotic fragility and lipid peroxidation

Yalçin A., Onaran I., YALÇIN A. S.

Epilepsy Research, vol.19, no.3, pp.249-252, 1994 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 3
  • Publication Date: 1994
  • Doi Number: 10.1016/0920-1211(94)90069-8
  • Title of Journal : Epilepsy Research
  • Page Numbers: pp.249-252


Epileptic children receiving antiepileptics were studied to investigate the effect of carbamazepine and phenobarbital therapy on erythrocyte osmotic fragility and lipid peroxidation. Significant differences between the two groups were observed in erythrocyte osmotic fragility. In addition, there was a significant increase in erythrocyte malondialdehyde release in the epileptic group compared to controls. It is suggested that the use of antioxidants in addition to antiepileptic drugs may be beneficial.