Pyrolidium dithiocarbamate prevents shockwave lithotripsy-induced renal injury through inhibition of nuclear factor-kappa B and inducible nitric oxide synthase activity in rats


Tugcu V., Bas M., Ozbek E., Kemahli E., Arıncı Y. V., Tuhri M., ...More

JOURNAL OF ENDOUROLOGY, vol.22, no.3, pp.559-566, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1089/end.2007.0295
  • Journal Name: JOURNAL OF ENDOUROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.559-566
  • Istanbul University Affiliated: Yes

Abstract

Purpose: Extracorporeal shockwave lithotripsy (SWL) is commonly used for treatment of renal stones. Free oxygen radicals are involved in the pathophysiology of renal injury due to SWL. We investigated the protective effect of pyrolidium dithiocarbamate (PDTC), an antioxidant and nuclear factor kappa-B (NF kappa-B) inhibitor, against renal injury.