The Multifactorial Role of Pre-supplementary Motor Area Stimulation in the Freezing of Gait: An Alternative Strategy to the Classical Drug-Target Approach

Saricaoglu M., Hanoglu L., Toprak G., Yilmaz N. H., Yulug B.

Endocrine, Metabolic and Immune Disorders - Drug Targets, vol.22, no.5, pp.518-524, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.2174/1871530321666211014170107
  • Journal Name: Endocrine, Metabolic and Immune Disorders - Drug Targets
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.518-524
  • Keywords: Freezing of gait, parkinson's disease, presupplementary area, repetitive transcranial magnetic stimulation, motor symptoms, cognitive symptoms, behavioural symptoms, TRANSCRANIAL MAGNETIC STIMULATION, OBSESSIVE-COMPULSIVE DISORDER, PARKINSONS-DISEASE, RTMS, CORTEX, OSCILLATIONS, EFFICACY, TRIAL, SMA
  • Istanbul University Affiliated: Yes

Abstract

© 2022 Bentham Science Publishers.Introduction: The pre-supplementary motor area (Pre-SMA) plays a pivotal role in the control of voluntary motor control and freezing of gait (FOG) pathophysiological mechanism. Here, we aimed to modulate if the pre-SMA would have beneficial effects on motor and behavioural outcomes in freezing of gait. To test this hypothesis, we examined the left pre-SMA stimulating effect of repetitive Transcranial Magnetic Stimulation (rTMS) on motor, cognitive and behavioural parameters in Parkinson’s patients with FOG. Methods: The study included 20 Parkinson’s patients with FOG (3 females, 17 males) who received the left Pre-SMA rTMS procedure. The clinical assessments were performed on all patients at the baseline and the patients were re-evaluated under the same clinical conditions one week after the end of the sessions. Results & Discussion: We found significant improvements in motor, cognitive and behavioural symptoms (p<0.05). The main finding of our study is that Pre-SMA is an attractive stimulation area leading to critical improvement of symptoms of Parkinson’s patients with FOG. Conclusion: The high-frequency rTMS stimulation over the left preSMA has a restorative effect on the motor, cognitive and behavioural symptoms of Parkinson’s patients with FOG.