MBL2 and MIF gene polymorphisms in cardiovascular patients with atherosclerotic lesions undergoing heart valve replacement

Eksi F., Pehlivan S., Erdogan M. B., Bayram A., Oguzkan-Balci S., YAMAK B., ...More

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, vol.31, no.6, pp.1173-1177, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 31 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1080/13102818.2017.1375864
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1173-1177
  • Keywords: Coronary bypass surgery, valve replacement, mannose binding lectin-2, migration inhibitory factor, gene polymorphisms, MANNOSE-BINDING-LECTIN, MIGRATION INHIBITORY FACTOR, RHEUMATOID-ARTHRITIS, ENDOTHELIAL DYSFUNCTION, ASSOCIATION, RISK, DISEASE
  • Istanbul University Affiliated: Yes


The basic underlying factor for cardiovascular diseases is atherosclerosis, which is a multifactorial disease driven by environmental and genetic factors. We aimed to study the genetic polymorphism in mannose binding lectin-2 (MBL2) and macrophage migration inhibitory factor (MIF) in the arteries of patients with atherosclerotic lesions who underwent cardiac valve replacement for cardiac valve stenosis. Thirty-five patients (38.9%) operated with coronary bypass surgery (coronary group, CG), 55 (61.1%) patients operated with aortic or mitral valve replacement (valve group, VG) and 100 healthy controls were analyzed for codon 54 A/B polymorphism in the MBL2 gene and -173G/C polymorphism in the MIF gene by using the method of polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The comparison of the healthy control group with CG and VG in terms of the MBL2 genotypes revealed significantly lower AA genotype and A allele ratios. The comparison of the healthy control group with CG and VG in terms of the MIF genotypes showed significantly lower GG genotype and G allele ratios. We suggest that the lower frequency of the GG genotype/G allele of the MIF gene and of the AA genotype/A allele of the MBL2 gene may be associated with the ethiopathogenesis of CG and VG patients.