Effects of profound hypothermia on the blood-brain barrier permeability in acute and chronically ethanol treated rats

Elmas I., Kucuk M., Kalayci R., Cevik A., Kaya M.

FORENSIC SCIENCE INTERNATIONAL, cilt.119, sa.2, ss.212-216, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 119 Sayı: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0379-0738(00)00429-1
  • Dergi Adı: FORENSIC SCIENCE INTERNATIONAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.212-216
  • İstanbul Üniversitesi Adresli: Evet

Özet

This study examines the effects of profound hypothermia on the blood-brain barrier (BBB) permeability in ethanol administrated rats. Vascular permeability to intravenously injected Evans blue (EB) was quantitatively examined in the brain regions of rats. Rats were treated with ethanol acute and chronically. Rectal temperature of rats was dropped into 20 +/- 1 degreesC during profound hypothermia. Mean arterial blood pressure in both acute and chronic ethanol treatments plus hypothermia significantly dropped into low levels as well as in hypothermia alone (P < 0.01). Hypothermia led to a significant increase in the content of EB dye in the brain regions of rats (P < 0.05). Both acute and chronic ethanol treatments plus hypothermia did not lead to a significant increase in the BBB permeability against intravenously injected EB dye. We conclude that ethanol intake protects the BBB against the effects of hypothermia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.