Peripheral blood NK cells expressing HLA-G, IL-10 and TGF-beta in healthy donors and breast cancer patients

Ostapchuk Y. O., Cetin E. A., Perfilyeva Y. V., Yilmaz A., Skiba Y. A., Chirkin A. P., ...Daha Fazla

CELLULAR IMMUNOLOGY, cilt.298, ss.37-46, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 298
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.cellimm.2015.09.002
  • Dergi Adı: CELLULAR IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.37-46
  • Anahtar Kelimeler: NK cells, IL-10, TGF-beta, HLA-G, Breast cancer, NATURAL-KILLER-CELLS, GROWTH-FACTOR-BETA, INHIBITORY RECEPTOR, CYTOKINE PRODUCTION, INNATE IMMUNITY, TUMOR-CELLS, IFN-GAMMA, T-CELLS, INTERLEUKIN-10, ANTIGEN
  • İstanbul Üniversitesi Adresli: Evet

Özet

Human natural killer (NK) cells are not only professional cytotoxic cells integrated into effector branch of innate immunity, but they are also regulatory cells, managing different immune processes. Immunoregulatory NK cells, expressing HLA-G and IL-10, have been generated in vitro from human hematopoietic progenitors and found in vivo among decidual NK cells of pregnant women. Human peripheral blood NK cells have been shown to acquire suppressive properties after HLA-G uptake during trogocytosis. Moreover, it has been shown that circulating NK cells contain a trace amount of cells producing TGF-beta and IL-10, which exert a suppressive influence upon innate and adaptive immunity. In this study, we report on a minor subset of peripheral blood HLA-G(+) NK cells possessing suppressive activity toward effector functions of NK cells. Further we demonstrate an increased number of circulating HLA-G+, IL-10(+), and TGF-beta(+) NK cells in breast cancer patients which might impair efficiency of anti-tumor immunity. (C) 2015 Elsevier Inc. All rights reserved.