Effects of betaine supplementation on nitric oxide metabolism, atherosclerotic parameters, and fatty liver in guinea pigs fed a high cholesterol plus methionine diet

Kusku-Kiraz Z., Genc S., Bekpinar S., Unlucerci Y., Cevik A., Olgac V., ...Daha Fazla

NUTRITION, cilt.45, ss.41-48, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.nut.2017.07.005
  • Dergi Adı: NUTRITION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.41-48
  • Anahtar Kelimeler: Betaine, Hypercholesterolemia, Hyperhomocysteinemia, NO bioavailability, Oxidative stress, Atherosclerosis, Liver, AMINO-ACID-METABOLISM, OXIDATIVE STRESS, ASYMMETRIC DIMETHYLARGININE, ENDOTHELIAL DYSFUNCTION, PLASMA HOMOCYSTEINE, TRIGLYCERIDE LEVELS, ANIMAL-TISSUES, DISEASE, RATS, SYNTHASE
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was to investigate the effect of high cholesterol (CHOL) and CHOL + methionine (MET) diets on atherogenic and oxidative index parameters and on the factors that influence nitric oxide (NO) bioavailability. Also, attempts were made to determine whether dietary betaine (BET) resulted in any improvement in the changes that occurred after CHOL + MET administration.