Effects of resveratrol on high-fructose-induced testis injury in rats

Meydanli E. G. , Gumusel A., Ozkan S. , Tanriverdi G. , Balci M. B. C. , Is S. D. , ...Daha Fazla

ULTRASTRUCTURAL PATHOLOGY, cilt.42, ss.65-73, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 42 Konu: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/01913123.2017.1397075
  • Sayfa Sayıları: ss.65-73


This study investigated whether a high-fructose (HFr) diet changes the morphology of seminiferous tubules (ST) in rats and resveratrol (RES) has a possible restoring effect in this sense. Fructose (30%; w/v) was administered to rats alone or together with RES (50 mg/L) in drinking water for 8 weeks. In the HFr group, destruction of the germinal epithelium led to the detection of immature germ cells in the lumen. HFr diet gave rise to a decrease in the ST diameters (p < 0.05), Johnsen's tubular biopsy score values (p < 0.001), and an increase in the apoptotic index (p < 0.05). Ultrastructurally, HFr feeding increased lipid accumulation (p < 0.01), mitochondrial damage, and acrosomal abnormalities in spermatogenic cells. Treatment of HFr-fed rats with RES improved the reduced ST diameters and overall general histological and ultrastructural abnormalities of the STs, but did not change the increased apoptotic index.