The aim of this study was to present the 31 year scientific research of Istanbul Faculty of Medicine (IFM) and to evaluate its national and international scientific contribution. The IFM addressed original research articles published in the 31-year period (January 1980-December 2010) were determined by using search engines PubMed, ISI Web of Sciences and Google Scholar were evaluated. A total of 4,728 IFM addressed original articles were identified [yearly mean: 151.5 +/- 145.9 (range:14-479)]. The IFM articles were 3.5% of all medical articles originated from Turkey between 1981 and 2007. One hundred and fourteen IFM articles published between 2005 and 2009 were originated from thesis (6.3% of total IFM articles between the same periods). The number of original IFM articles in 1980 was 23 and increased to 443 in 2010. The highest numbers of articles were published in the field of Internal Medicine, followed by Surgery and Basic Sciences during the 31 year period. In the last 12 years, the highest number of articles per faculty was found in the Department of Medical Genetics (2.6/faculty/year) in the field of Internal Medicine, Department of Heart and Vascular Surgery (1.87/faculty/year) in the field of Surgery and Department of Medical Biology (1.05/faculty/year) in the field of Basic Science. The number of articles increased from 0.2 to 1 per faculty between the same periods. Until the end of 2011 the total citations were 28,750, with an impact of 6.08.The number of articles with higher than 50 citations were 412. Istanbul Faculty of Medicine with its 4,728 original articles between 1980 and 2010 contributed crucially to scientific reproduction of our country. With a scientific acceleration in the last decade, Istanbul Faculty of Medicine contributed notably for Istanbul University to become the 383rd in general and 156th in the field of medicine among the leading universities of the world.