TUMORI J, vol.96, no.5, pp.756-763, 2010 (Journal Indexed in SCI)
Article / Article
Title of Journal :
microsomal epoxide hydrolase, lung cancer, exons 3 and 4 polymorphism, metastasis, XENOBIOTIC-METABOLIZING ENZYMES, SQUAMOUS-CELL-CARCINOMA, S-TRANSFERASE M1, ASSOCIATION, RISK, SMOKING, OXIDOREDUCTASE, CYP1A1, LIVER, DNA
Aims and background. The aim of this study was to investigate the relationship between EPHXI exon 3 Tyr113His and exon 4 His139Arg polymorphisms, predicted microsomal epoxide hydrolase (mEH) activity, and lung cancer development. mEH is a protective enzyme involved in oxidative defences against a number of environmental chemicals and pollutants, but it is also responsible for the xenobiotic activation of carcinogens.