Polymorphisms in the microsomal epoxide hydrolase gene: role in lung cancer susceptibility and prognosis

Erkisi Z., Yaylim-Eraltan I. , Turna A. , Gormus U., Camlica H., Isbir T.

TUMORI J, cilt.96, ss.756-763, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 96 Konu: 5
  • Basım Tarihi: 2010
  • Dergi Adı: TUMORI J
  • Sayfa Sayıları: ss.756-763


Aims and background. The aim of this study was to investigate the relationship between EPHXI exon 3 Tyr113His and exon 4 His139Arg polymorphisms, predicted microsomal epoxide hydrolase (mEH) activity, and lung cancer development. mEH is a protective enzyme involved in oxidative defences against a number of environmental chemicals and pollutants, but it is also responsible for the xenobiotic activation of carcinogens.