Polymorphisms in the microsomal epoxide hydrolase gene: role in lung cancer susceptibility and prognosis

Erkisi Z., Yaylim-Eraltan I. , Turna A. , Gormus U., Camlica H., Isbir T.

TUMORI J, vol.96, no.5, pp.756-763, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 96 Issue: 5
  • Publication Date: 2010
  • Title of Journal : TUMORI J
  • Page Numbers: pp.756-763
  • Keywords: microsomal epoxide hydrolase, lung cancer, exons 3 and 4 polymorphism, metastasis, XENOBIOTIC-METABOLIZING ENZYMES, SQUAMOUS-CELL-CARCINOMA, S-TRANSFERASE M1, ASSOCIATION, RISK, SMOKING, OXIDOREDUCTASE, CYP1A1, LIVER, DNA

Abstract

Aims and background. The aim of this study was to investigate the relationship between EPHXI exon 3 Tyr113His and exon 4 His139Arg polymorphisms, predicted microsomal epoxide hydrolase (mEH) activity, and lung cancer development. mEH is a protective enzyme involved in oxidative defences against a number of environmental chemicals and pollutants, but it is also responsible for the xenobiotic activation of carcinogens.