Akademik Veri Yönetim Sistemi
XXI World Congress of Echocardiograpy and Cardiolgy, İstanbul, Türkiye, 20 - 22 Kasım 2015, ss.39
Objective: After MI, LV remodelling is one of the
major causes of death. We previously showed the NO
mediated beneficial effects of nebivolol in rat MI model, in
this study we aimed to determine the source of NO.
Methods: Rats were divided into four groups: sham
operated (sham-control), MI-induced (MI-control), immediate nebivolol loaded (MI-neb1), orally nebivolol treated
(MI-neb2). MI was induced by the ligation of the LAD.
NOS related mechanisms were assessed either in acute
and sub-acute period of MI by histologic, hemodynamic
and biologic studies.
Results: Compared to MI-control rats, physiological
functions of LV (LVEDP, D!dp/dt) were prevented in nebivolol treated groups. Improvements in anatomical parameters (LEV, HW, LVW/HW) were consistent with functional
improvement. Oxidative (decreased MDA, increased
SOD) and nitrosative (decreased ONOO-) damage were
limited also. Most dramatic change was seen in the nNOS
labelling.The decrease in iNOS labelling was also prominent too.
Conclusions: NOS mediated mechanisms of nebivolol can be summarized as: 1) diminishing iNOS expression together with restoration of MI induced eNOS
activation both in vascular bed and myocytes at the acute
period of MI, and 2) prevention of deterioration in nNOS
expression in myocardial cells at the sub-acute period of
MI.