Common Crohn's disease-predisposing variants of the CARD15/NOD2 gene are not associated with Behcet's disease in Turkey

Uyar F. A., Saruhan-Direskeneli G., Gul A.

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol.22, no.4, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 4
  • Publication Date: 2004
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Behcet's disease, Crohn's disease, CARD15, NOD2, genetic susceptibility, NOD2, SUSCEPTIBILITY, MUTATIONS, DIAGNOSIS, ARTHRITIS, SYNDROME/, CRITERIA, LOCUS
  • Istanbul University Affiliated: Yes


Objective. There are many extra-intestinal findings of Crohn's disease (CD), such as oral and genital ulcers, erythema nodosum, uveitis and arthritis, resembling the manifestations of Behcet's disease (BD). It is also very difficult to distinguish the gastrointestinal involvement of BD from that of CD in some patients. Hence, this study aimed to investigate a possible involvement of the common CD-predisposing CARD15 variants in the genetic susceptibility to BD.