Genetic deficiency of estrogen receptor alpha fails to influence experimental autoimmune myasthenia gravis pathogenesis

QI H., LI J., ALLMAN W., SAINI S. S., Tuezuen E., WU X., ...Daha Fazla

JOURNAL OF NEUROIMMUNOLOGY, cilt.234, ss.165-167, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 234
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.jneuroim.2011.03.002
  • Dergi Adı: JOURNAL OF NEUROIMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.165-167
  • İstanbul Üniversitesi Adresli: Evet

Özet

Autoimmune myasthenia gravis (MG) is characterized by T cell and antibody responses to muscle nicotinic acetylcholine receptor (AChR). It is well known that MG as other autoimmune diseases is more prevalent in women than men and estrogen administration enhances experimental autoimmune MG (EAMG) severity. To determine whether estrogen influences EAMG pathogenesis through estrogen receptor alpha (ER alpha) activation, ER alpha knockout (KO) and wild-type (WT) C57BL/6 mice were immunized with AChR. ER alpha KO mice were equally susceptible to EAMG as WT mice and exhibited comparable antibody and immunopathological responses to AChR, suggesting a lack of involvement of ERa in EAMG pathogenesis. (C) 2011 Elsevier B.V. All rights reserved.