Serum IgG of patients with relapsing inflammatory optic neuropathy immunoreacts with Sox2-positive glial cells of the optic nerve

Erdağ E., Emekli A. S., Gündüz T., Küçükali C. İ., Kürtüncü M., Tüzün E.

MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol.73, 2023 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 73
  • Publication Date: 2023
  • Doi Number: 10.1016/j.msard.2023.104694
  • Journal Name: MULTIPLE SCLEROSIS AND RELATED DISORDERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, MEDLINE
  • Keywords: Antibody, Autoimmunity, Glia, Optic neuritis, Sox2
  • Istanbul University Affiliated: Yes

Abstract

Background: Given the significance of glial cells in maintenance of neurons, antibodies directed against glial cells of the optic nerve might reasonably be expected to have a pathogenic impact in relapsing inflammatory optic neuropathy (RION).Methods: We investigated IgG immunoreactive with the optic nerve tissue by indirect immunohistochemistry using sera of 20 RION patients. Commercial Sox2-antibody was used for double immunolabeling.Results: Serum IgG of 5 RION patients reacted with cells aligned in the interfascicular regions of the optic nerve. IgG binding sites significantly co-localized with the Sox2-antibody.Conclusion: Our results suggest that a subset of RION patients may harbor anti-glial antibodies.