Sister chromatid exchanges in lymphocytes of nuclear medicine physicians

Bozkurt G., Yuksel M., Karabogaz G., Sut N., Savran F., Palanduz S., ...More

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, vol.535, no.2, pp.205-213, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 535 Issue: 2
  • Publication Date: 2003
  • Doi Number: 10.1016/s1383-5718(02)00321-2
  • Journal Name: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.205-213
  • Keywords: nuclear medicine, genotoxicity, sister chromatid exchange, occupational exposure, PERIPHERAL-BLOOD LYMPHOCYTES, IONIZING-RADIATION, ALPHA-PARTICLES, URANIUM MINERS, CELLS, FREQUENCY, EXPOSURE, INDUCTION, SCE, DNA
  • Istanbul University Affiliated: Yes

Abstract

Objective: The aim of this study was to assess whether occupational exposure to chronic, low doses of Iodine 131 (I-131) and Technetium 99m (Tc-99m) may lead to genotoxicity. Medical personnel occupied in nuclear medicine departments are occupationally exposed to low doses of I-131 and Tc-99m. The determination of the frequency of sister chromatid exchanges (SCEs) and of cells with a high frequency of SCEs (HFC) is considered to be a sensitive indicator for detecting genotoxic potential of mutagenic and carcinogenic agents. Therefore, we examined peripheral lymphocytes from nuclear medicine physicians for the presence of both SCE and HFC.