Identification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens


Karatas O. F. , Suer İ., Yuceturk B., Yilmaz M., Oz B., Guven G., ...More

BMC CANCER, vol.16, 2016 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16
  • Publication Date: 2016
  • Doi Number: 10.1186/s12885-016-2863-3
  • Journal Name: BMC CANCER
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: Cancer stem-like cells, MicroRNAs, Larynx cancer, CD133, microRNA-signature, EPITHELIAL-MESENCHYMAL TRANSITION, TUMOR-INITIATING CELLS, COUPLED RECEPTOR GPR49, EXPRESSION SIGNATURE, PROSTATE-CANCER, SMALL-INTESTINE, MIR-200 FAMILY, SELF-RENEWAL, E-CADHERIN, CARCINOMA

Abstract

Background: Emerging evidences proposed that microRNAs are associated with regulation of distinct physiopathological processes including development of normal stem cells and carcinogenesis. In this study we aimed to investigate microRNA profile of cancer stem-like cells (CSLCs) isolated form freshly resected larynx cancer (LCa) tissue samples.